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Red blood cell (RBC) transfusions result in the sequestration and metabolism of storage‐damaged RBCs within the spleen and liver. These events are followed by increased plasma iron concentrations that can… Click to show full abstract
Red blood cell (RBC) transfusions result in the sequestration and metabolism of storage‐damaged RBCs within the spleen and liver. These events are followed by increased plasma iron concentrations that can contribute to oxidant stress and cellular injury. We hypothesized that administration of a ferroportin inhibitor (FPN‐INH) immediately after acute RBC exchange transfusion could attenuate posttransfusion circulatory compartment iron exposure, by retaining iron in spleen and hepatic macrophages.
Keywords:
red blood;
plasma iron;
oxidant stress;
transfusion;
blood cell;
iron
Journal Title: Transfusion
Year Published: 2020
Link to full text (if available)
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Journal Title: Transfusion
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!