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Inactivation of Plasmodium falciparum in whole blood using the amustaline and glutathione pathogen reduction technology

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Risk of transfusion‐transmitted (TT) malaria is mainly associated with whole blood (WB) or red blood cell (RBC) transfusion. Risk mitigation relies mostly on donor deferral while a limited number of… Click to show full abstract

Risk of transfusion‐transmitted (TT) malaria is mainly associated with whole blood (WB) or red blood cell (RBC) transfusion. Risk mitigation relies mostly on donor deferral while a limited number of countries perform blood testing, both negatively impacting blood availability. This study investigated the efficacy of the pathogen reduction system using amustaline and glutathione (GSH) to inactivate Plasmodium falciparum in WB.

Keywords: using amustaline; plasmodium falciparum; blood; pathogen reduction; whole blood; amustaline glutathione

Journal Title: Transfusion
Year Published: 2020

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