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During platelet storage, there are extensive changes in cytoskeleton and phosphatidylserine exposure. The intrinsic mitochondrial pathway of apoptosis, activated in stored platelets, is a major mediator these changes. Cofilin‐1 is… Click to show full abstract
During platelet storage, there are extensive changes in cytoskeleton and phosphatidylserine exposure. The intrinsic mitochondrial pathway of apoptosis, activated in stored platelets, is a major mediator these changes. Cofilin‐1 is an effector of actin reorganization. We examined the effect of cofilin‐1 deficiency on cytoskeleton and phosphatidylserine exposure during storage and following activation of apoptosis.
Keywords:
reorganization stored;
stored platelets;
induced actin;
actin reorganization;
cofilin induced
Journal Title: Transfusion
Year Published: 2020
Link to full text (if available)
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Journal Title: Transfusion
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!