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Calcium chelation: a novel approach to reduce cryopreservation‐induced damage to frozen platelets

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Cryopreserved platelets are phenotypically and functionally different to conventionally stored platelets. Calcium may be released from internal stores during the freeze–thaw process, initiating signaling events which lead to these alterations.… Click to show full abstract

Cryopreserved platelets are phenotypically and functionally different to conventionally stored platelets. Calcium may be released from internal stores during the freeze–thaw process, initiating signaling events which lead to these alterations. It was hypothesized that the addition of a calcium chelator prior to cryopreservation may mitigate some of these changes.

Keywords: calcium chelation; novel approach; chelation novel; approach reduce; cryopreservation; platelets calcium

Journal Title: Transfusion
Year Published: 2020

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