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Screening for new red blood cell alloantibodies after transfusion in patients with sickle cell disease

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Patients with sickle cell disease (SCD) are frequent recipients of red blood cell (RBC) transfusions and are at risk for RBC alloimmunization. RBC alloimmunization is diagnosed by identifying RBC alloantibodies… Click to show full abstract

Patients with sickle cell disease (SCD) are frequent recipients of red blood cell (RBC) transfusions and are at risk for RBC alloimmunization. RBC alloimmunization is diagnosed by identifying RBC alloantibodies as part of preā€transfusion testing, but this testing fails to detect alloantibodies that have evanesced. It may be beneficial to screen for new RBC alloantibody development after transfusion before possible antibody evanescence.

Keywords: red blood; patients sickle; transfusion; cell disease; cell; sickle cell

Journal Title: Transfusion
Year Published: 2021

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