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Gamma and X‐ray irradiation do not affect the in vitro quality of refrigerated apheresis platelets in platelet additive solution (PAS‐E)

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Platelet refrigeration (cold storage) provides the advantages of an extended shelf life and reduces the risk of bacterial growth, compared to platelets stored at room temperature (RT). However, processing modifications,… Click to show full abstract

Platelet refrigeration (cold storage) provides the advantages of an extended shelf life and reduces the risk of bacterial growth, compared to platelets stored at room temperature (RT). However, processing modifications, such as irradiation, may further improve the safety and/or alter the quality of cold‐stored platelets. Platelet components are irradiated to prevent transfusion‐associated graft versus host disease (TA‐GvHD) in high‐risk patients; and while irradiation has little effect on the quality of RT‐stored platelet components, there is no data assessing the effect irradiation has following cold storage.

Keywords: irradiation affect; quality; platelets platelet; gamma ray; ray irradiation; irradiation

Journal Title: Transfusion
Year Published: 2022

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