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ABO, secretor, and Lewis carbohydrate histo‐blood groups are associated with autoimmune neutropenia of early childhood in Danish patients

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Autoimmune neutropenia of early childhood (AIN) is caused by autoantibodies directed against antigens on the neutrophil membrane. The ABO, secretor, and Lewis histo‐blood group systems control the expression of carbohydrate… Click to show full abstract

Autoimmune neutropenia of early childhood (AIN) is caused by autoantibodies directed against antigens on the neutrophil membrane. The ABO, secretor, and Lewis histo‐blood group systems control the expression of carbohydrate antigens and have previously been linked to autoimmune diseases. We aimed to investigate the association between genotypes and the risk of AIN in Danish patients.

Keywords: secretor lewis; early childhood; histo blood; neutropenia early; autoimmune neutropenia; abo secretor

Journal Title: Transfusion
Year Published: 2022

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