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Cold‐stored platelet function is not significantly altered by agitation or manual mixing

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Cold storage of platelets (CS‐PLT), results in better maintained hemostatic function compared to room‐temperature stored platelets (RT‐PLT), leading to increased interest and use of CS‐PLT for actively bleeding patients. However,… Click to show full abstract

Cold storage of platelets (CS‐PLT), results in better maintained hemostatic function compared to room‐temperature stored platelets (RT‐PLT), leading to increased interest and use of CS‐PLT for actively bleeding patients. However, questions remain on best storage practices for CS‐PLT, as agitation of CS‐PLT is optional per the United States Food and Drug Administration. CS‐PLT storage and handling protocols needed to be determined prior to upcoming clinical trials, and blood banking standard operating procedures need to be updated accordingly for the release of units due to potentially modified aggregate morphology without agitation.

Keywords: function; function significantly; agitation; platelet function; cold stored; stored platelet

Journal Title: Transfusion
Year Published: 2022

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