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Two novel platelet biotinylation methods and their impact on stored platelet concentrates in a blood bank environment

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Storage of platelet concentrates (PCs) has an impact on platelet quality and possibly affects their functions after transfusion. The influence of processing and storage conditions of PCs on their in… Click to show full abstract

Storage of platelet concentrates (PCs) has an impact on platelet quality and possibly affects their functions after transfusion. The influence of processing and storage conditions of PCs on their in vivo function upon transfusion is unknown. One option for investigating this question is to implement an ex vivo labeling of human platelets, to analyze them after transfusion into heathy volunteers and/or patients. In this study, we developed two labeling methods employing biotin.

Keywords: impact; platelet concentrates; novel platelet; platelet; transfusion; two novel

Journal Title: Transfusion
Year Published: 2022

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