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Donor variation in stored platelets: Higher metabolic rates of platelets are associated with mean platelet volume, activation and donor health

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Platelets (PLTs) differ in glycolytic activity, resulting in rapid acidification of ‘poor’ storing PLT concentrates (PCs) in plasma, or depletion of glucose when stored in PLT additive solution (PAS). We… Click to show full abstract

Platelets (PLTs) differ in glycolytic activity, resulting in rapid acidification of ‘poor’ storing PLT concentrates (PCs) in plasma, or depletion of glucose when stored in PLT additive solution (PAS). We aimed to understand why PLT glycolysis rates vary between donors and how this affects storage performance.

Keywords: donor; higher metabolic; stored platelets; platelets higher; donor variation; variation stored

Journal Title: Transfusion
Year Published: 2022

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