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The role of RBC antigen transgene integration sites on RBC biology in mice

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Transgenic mice expressing RBC specific antigens are widely used in mechanistic studies of RBC alloimmunization. Existing RBC donor strains have random transgene integration, potentially disrupting host elements that can confound… Click to show full abstract

Transgenic mice expressing RBC specific antigens are widely used in mechanistic studies of RBC alloimmunization. Existing RBC donor strains have random transgene integration, potentially disrupting host elements that can confound biological interpretation.

Keywords: rbc antigen; transgene integration; antigen transgene; role rbc; biology

Journal Title: Transfusion
Year Published: 2022

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