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Mitigation of therapeutic anti‐CD38 antibody interference with fab fragments: How well does it perform?

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Administration of anti‐CD38 antibodies is a state‐of‐the‐art therapy for patients diagnosed with multiple myeloma (MM). However, this treatment frequently leads to pan‐agglutination of red blood cells (RBCs) in patients' serological… Click to show full abstract

Administration of anti‐CD38 antibodies is a state‐of‐the‐art therapy for patients diagnosed with multiple myeloma (MM). However, this treatment frequently leads to pan‐agglutination of red blood cells (RBCs) in patients' serological testing making accurate blood typing and timely transfusion of compatible blood a challenging effort. The antigen masking indirect antiglobulin test (AMIAT) is an approach to address this diagnostic challenge.

Keywords: anti cd38; cd38 antibody; interference fab; antibody interference; mitigation therapeutic; therapeutic anti

Journal Title: Transfusion
Year Published: 2023

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