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Different‐sized extracellular vesicles derived from stored red blood cells package diverse cargoes and cause distinct cellular effects

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The formation of extracellular vesicles (EVs) occurs during cold storage of RBCs. Transfusion of EVs may contribute to adverse responses in recipients receiving RBCs. However, EVs are poorly characterized with… Click to show full abstract

The formation of extracellular vesicles (EVs) occurs during cold storage of RBCs. Transfusion of EVs may contribute to adverse responses in recipients receiving RBCs. However, EVs are poorly characterized with limited data on whether distinct vesicles are formed, their composition, and potential biological effects.

Keywords: different sized; extracellular vesicles; sized extracellular; stored red; derived stored; vesicles derived

Journal Title: Transfusion
Year Published: 2023

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