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Tranexamic acid (TXA) is widely used as an antifibrinolytic agent in hemorrhagic trauma patients. The beneficial effects of TXA exceed the suppression of blood loss and include the ability to… Click to show full abstract
Tranexamic acid (TXA) is widely used as an antifibrinolytic agent in hemorrhagic trauma patients. The beneficial effects of TXA exceed the suppression of blood loss and include the ability to decrease inflammation and edema. We found that TXA suppresses the release of mitochondrial DNA and enhances mitochondrial respiration. These results allude that TXA could operate through plasmin‐independent mechanisms. To address this hypothesis, we compared the effects of TXA on lipopolysaccharide (LPS)‐induced expression of proinflammatory cytokines in plasminogen (Plg) null and Plg heterozygous mice.
Journal Title: Transfusion
Year Published: 2023
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