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Transient severe anemia triggered by parvovirus B19 infection in a patient with homozygous RhAG deficiency

Deficiency of Rh antigens affects the red blood cell (RBC) membrane integrity, thus reducing erythrocyte survival, clinically manifesting as chronic hemolytic anemia. Various mutations cause such Rhnull/mod phenotypes. Parvovirus B19… Click to show full abstract

Deficiency of Rh antigens affects the red blood cell (RBC) membrane integrity, thus reducing erythrocyte survival, clinically manifesting as chronic hemolytic anemia. Various mutations cause such Rhnull/mod phenotypes. Parvovirus B19 infection causes transient red cell aplasia, leading to potentially severe anemia in patients with chronic hemolytic disorders.

Keywords: parvovirus b19; severe anemia; b19 infection; anemia; deficiency

Journal Title: Transfusion
Year Published: 2025

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