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Paediatric practice recommendations on the use of tacrolimus following kidney transplantation are largely based on the experience from adult solid organ recipients. It has been reported that adequate tacrolimus exposure… Click to show full abstract
Paediatric practice recommendations on the use of tacrolimus following kidney transplantation are largely based on the experience from adult solid organ recipients. It has been reported that adequate tacrolimus exposure in adults can impact patient outcomes. As shown in the SYMPHONY trial, adult de novo kidney transplant patients with a target tacrolimus pre-dose concentration (TAC C0 ) of 3-7 ng/ml had a higher glomerular filtration rate and a lower incidence of acute rejection one year following transplantation compared to those treated with cyclosporine A or sirolimus.
Journal Title: Transplant International
Year Published: 2020
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