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Sickle red blood cells are more susceptible to in vitro haemolysis when exposed to normal saline versus Plasma‐Lyte A

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Normal saline has been the fluid of choice for resuscitation, rehydration and fluid replacement during plasma or red cell exchange/cytapheresis. There are increased concerns about its clinical effects and data… Click to show full abstract

Normal saline has been the fluid of choice for resuscitation, rehydration and fluid replacement during plasma or red cell exchange/cytapheresis. There are increased concerns about its clinical effects and data showing it causes more haemolysis in vitro than buffered solutions such as Plasma‐Lyte A.

Keywords: red blood; sickle red; normal saline; plasma lyte; haemolysis

Journal Title: Vox Sanguinis
Year Published: 2019

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