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Direct comparison of three residual risk models for hepatitis B virus window period infections using updated input parameters

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Comparison of two models for estimating residual transfusion transmission risk by NAT screened window period (WP) donations in South African repeat donors gave identical results for HIV but not for… Click to show full abstract

Comparison of two models for estimating residual transfusion transmission risk by NAT screened window period (WP) donations in South African repeat donors gave identical results for HIV but not for HBV. In order to understand discrepant HBV modelling outcomes, the values of input parameters in three HBV WP risk models were reviewed and subsequently applied to the same South African screening data generated by HBsAg PRISM and two NAT assays (Ultrio and Ultrio Plus). Two of the models were also compared using individual donation (ID)‐NAT screening data from different geographical regions.

Keywords: window period; risk; input parameters; risk models; comparison

Journal Title: Vox Sanguinis
Year Published: 2020

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