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Fatal haemolytic transfusion reaction due to anti‐Ena and identification of a novel GYPA c.295delG variant in a Thai family

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High‐frequency antigen Ena (MNS 28) is expressed on glycophorin A (GPA). En(a−) individuals can form anti‐Ena when exposed to GPA. A Thai patient formed an antibody that reacted against all… Click to show full abstract

High‐frequency antigen Ena (MNS 28) is expressed on glycophorin A (GPA). En(a−) individuals can form anti‐Ena when exposed to GPA. A Thai patient formed an antibody that reacted against all reagent red blood cells (RBCs). The patient received incompatible blood resulting in a fatal haemolytic transfusion reaction (HTR). This study aimed to characterize the antibody detected in the patient and investigate the cause of HTR.

Keywords: transfusion reaction; haemolytic transfusion; anti ena; fatal haemolytic

Journal Title: Vox Sanguinis
Year Published: 2022

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