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Basophil activation test for allergic and febrile non‐haemolytic transfusion reactions among paediatric patients with haematological or oncological disease

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Allergic transfusion reactions (ATRs) and febrile non‐haemolytic transfusion reactions (FNHTRs) are common, although their mechanisms remain unclear. Immunoglobulin E (IgE)‐mediated type I hypersensitivity may be involved in the pathogenesis of… Click to show full abstract

Allergic transfusion reactions (ATRs) and febrile non‐haemolytic transfusion reactions (FNHTRs) are common, although their mechanisms remain unclear. Immunoglobulin E (IgE)‐mediated type I hypersensitivity may be involved in the pathogenesis of ATR. A basophil activation test (BAT) may help elucidate this process.

Keywords: haemolytic transfusion; basophil activation; febrile non; non haemolytic; transfusion reactions; transfusion

Journal Title: Vox Sanguinis
Year Published: 2022

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