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In pig‐to‐human xenotransplantation, hyperacute rejection of pig organs could be overcome by the production of α1,3‐galactosyltransferase knockout pigs. However, macrophage‐mediated acute rejection is another obstacle that needs to be overcome.… Click to show full abstract
In pig‐to‐human xenotransplantation, hyperacute rejection of pig organs could be overcome by the production of α1,3‐galactosyltransferase knockout pigs. However, macrophage‐mediated acute rejection is another obstacle that needs to be overcome. Among the various candidate genes involved in acute rejection, CD47 inhibits monocyte/macrophage‐mediated phagocytosis by identifying the CD47 signal regulatory protein alpha (SIRP‐α) as self/non‐self. Tissue factor pathway inhibitor (TFPI) is involved in the regulation of the coagulation pathway and is able to bind to another ligand of CD47, thrombospondin‐1 (TSP‐1). When TSP‐1 binds to CD47, phagocytosis in macrophages is increased.
Journal Title: Xenotransplantation
Year Published: 2017
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