LAUSR

What is the central question of this study? The main aim of the present study was to determine the effect of prolonged moderate‐intensity endurance training on the endothelial glycocalyx layer integrity in relationship to the training‐induced changes in oxidative stress and antioxidant defence in humans. What is the main finding and its importance? We have shown, for the first time, a protective effect of prolonged moderate‐intensity endurance training on endothelial glycocalyx layer integrity, as judged by significantly lower basal and end‐exercise serum concentrations of glycocalyx damage markers, i.e. syndecan‐1 and heparan sulfate, accompanied by attenuation of oxidative stress and enhancement of antioxidant defence after training in previously untrained healthy young men.