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Blunted cerebral vascular responsiveness to hypercapnia in obese individuals

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What is the central question of this study? Is there a difference in the cerebral vascular response to rebreathing‐induced hypercapnia between obese and lean individuals? What is the main finding… Click to show full abstract

What is the central question of this study? Is there a difference in the cerebral vascular response to rebreathing‐induced hypercapnia between obese and lean individuals? What is the main finding and its importance? The main finding is that obese individuals have an attenuated increase in cerebral vascular conductance during hypercapnia relative to lean individuals. This finding suggests cerebral vascular dysfunction in this population, which might contribute to the greater prevalence of cerebral vascular and neurocognitive disease in this population.

Keywords: hypercapnia; blunted cerebral; obese individuals; cerebral vascular; hypercapnia obese; vascular responsiveness

Journal Title: Experimental Physiology
Year Published: 2017

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