What is the central question of this study? The liver X receptor (LXR) has been reported to regulate several membrane transporters. It is imperative to investigate whether LXR activation regulates… Click to show full abstract
What is the central question of this study? The liver X receptor (LXR) has been reported to regulate several membrane transporters. It is imperative to investigate whether LXR activation regulates SGLT2‐mediated glucose transport in human renal proximal tubular cells. What is the main finding and its importance? Liver X receptor activation inhibits SGLT2 transport function in normal and high‐glucose conditions via reduction of SGLT2 protein expression.
Keywords:
sglt2 mediated;
liver receptor;
glucose transport;
transport human;
activation;
mediated glucose
Journal Title: Experimental Physiology
Year Published: 2018
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Journal Title: Experimental Physiology
Year Published: 2018
Link to full text (if available)
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recommendations!