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What is the central question of this study? To investigate haemodynamic dysfunction in the type 2 diabetic Goto‐Kakizaki (GK) rat, we measured shortening and Ca2+ transport in ventricular myocytes from… Click to show full abstract
What is the central question of this study? To investigate haemodynamic dysfunction in the type 2 diabetic Goto‐Kakizaki (GK) rat, we measured shortening and Ca2+ transport in ventricular myocytes from epicardial (EPI) and endocardial (ENDO) regions. What is the main finding and its importance? EPI and ENDO GK myocytes displayed similar hypertrophy. Time to peak (TPK) and time to half (THALF) relaxation were prolonged in EPI GK myocytes. TPK Ca2+ transient was prolonged and THALF decay of the Ca2+ transient was shortened in EPI GK myocytes. Amplitude of shortening, Ca2+ transient and sarcoplasmic reticulum Ca2+ were unaltered in EPI and ENDO myocytes from Goto‐Kakizaki compared with control rats. We demostrated regional differences in shortening and Ca2+ transport in Goto‐Kakizaki rats.
Journal Title: Experimental Physiology
Year Published: 2018
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