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Regulation of muscle protein synthesis in an in vitro cell model using ex vivo human serum

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What is the central question of this study? Can medium conditioned by ex vivo human serum regulate muscle protein synthesis in skeletal muscle cells in vitro? What is the main… Click to show full abstract

What is the central question of this study? Can medium conditioned by ex vivo human serum regulate muscle protein synthesis in skeletal muscle cells in vitro? What is the main finding and its importance? This study demonstrates that medium conditioned by ex vivo human serum can regulate muscle protein synthesis in skeletal muscle cells in vitro via the mammalian Target of Rapomycin (mTOR) pathway, and this can be regulated differentially by fed and fasted ex vivo human serum.

Keywords: muscle protein; muscle; human serum; protein synthesis; vivo human

Journal Title: Experimental Physiology
Year Published: 2018

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