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Sodium nitroglycerin induces middle cerebral artery vasodilatation in young, healthy adults

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What is the central question of this study? Nitric oxide causes dilatation in peripheral vessels; however, whether nitric oxide affects basal cerebral artery dilatation has not been explored. What is… Click to show full abstract

What is the central question of this study? Nitric oxide causes dilatation in peripheral vessels; however, whether nitric oxide affects basal cerebral artery dilatation has not been explored. What is the main finding and its importance? This study demonstrated that vasodilatation occurs in the right middle cerebral artery in response to exogenous nitric oxide. However, blood velocity decreased and, therefore, overall cerebral blood flow remained unchanged. This study provides new insight into the role of nitric oxide in cerebral blood flow control.

Keywords: cerebral artery; artery; vasodilatation; sodium nitroglycerin; middle cerebral; nitric oxide

Journal Title: Experimental Physiology
Year Published: 2018

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