LAUSR

What is the central question of this study? Do females and males exhibit a similar sarcopenic response as a consequence of normoxic and hypoxic bed rest? What is the main finding and its importance? During 10‐day bed rest, exposure to a simulated (normobaric hypoxia) altitude of ∼4000 m does not exert additional significant structural or functional effect on the weight‐bearing muscles in females compared to those noted under normoxic conditions. Whereas males and females exhibit decrements in muscle cross‐sectional area and mass during normoxic and hypoxic bed rest, a concomitant strength decrement was only observed in males.