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What is the central question of this study? We sought to assess the effects of intermittent parathyroid hormone (1–34) administration on bone angiogenesis, the redistribution of bone marrow blood vessels,… Click to show full abstract
What is the central question of this study? We sought to assess the effects of intermittent parathyroid hormone (1–34) administration on bone angiogenesis, the redistribution of bone marrow blood vessels, and matrix metalloproteinase 9 as a function of advancing age in mice. What is the main finding and its importance? Short‐term (i.e. 10 days) intermittent parathyroid hormone (1–34) administration increased the number of small (≤29‐µm‐diameter) bone marrow blood vessels and augmented matrix metalloproteinase 9. These changes occurred before alterations in trabecular bone. Given the rapid response in bone angiogenesis, this investigation highlights the impact of intermittent parathyroid hormone (1–34) administration on the bone vascular network.
Journal Title: Experimental Physiology
Year Published: 2020
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