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What is the central question of this study? What is the immediate impact of moderate preterm birth on the structure and function of major conduit arteries using a pre‐clinical sheep… Click to show full abstract
What is the central question of this study? What is the immediate impact of moderate preterm birth on the structure and function of major conduit arteries using a pre‐clinical sheep model? What is the main finding and its importance? Postnatal changes in conduit arteries, including a significant decrease in collagen within the thoracic aortic wall (predominately males), narrowed carotid arteries, reduced aortic systolic blood flow, and upregulation of the mRNA expression of cell adhesion and inflammatory markers at 2 days of age in preterm lambs compared to controls, may increase the risk of cardiovascular impairment in later life.
Journal Title: Experimental Physiology
Year Published: 2020
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