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MiR‐92b‐3p regulates oxygen and glucose deprivation–reperfusion‐mediated apoptosis and inflammation by targeting TRAF3 in PC12 cells

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What is the central question of this study? MiR‐92b‐3p was found to be reduced in a rat model of middle cerebral artery occlusion: what are the functions of miR‐92b‐3p in… Click to show full abstract

What is the central question of this study? MiR‐92b‐3p was found to be reduced in a rat model of middle cerebral artery occlusion: what are the functions of miR‐92b‐3p in oxygen and glucose deprivation–reperfusion (OGD/R)? What is the main finding and its importance? MiR‐92b‐3p abated apoptosis, mitochondrial dysfunction and inflammation caused by OGD/R via targeting TRAF3, suggesting that miR‐92b‐3p may serve as a potential therapeutic target in ischaemic stroke treatment.

Keywords: glucose deprivation; oxygen glucose; mir 92b; targeting traf3; deprivation reperfusion

Journal Title: Experimental Physiology
Year Published: 2020

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