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What is the central question of this study? Is there a causal relationship between gonadotrophin‐releasing hormone (GnRH) receptor‐activating autoantibodies and polycystic ovary syndrome (PCOS)? What is the main finding and… Click to show full abstract
What is the central question of this study? Is there a causal relationship between gonadotrophin‐releasing hormone (GnRH) receptor‐activating autoantibodies and polycystic ovary syndrome (PCOS)? What is the main finding and its importance? Induction of GnRH receptor‐activating autoantibodies in rats resulted in increased luteinizing hormone pulsatility and testosterone concentrations, disrupted oestrous cycles, increased atretic follicles, and activation of insulin signalling in the pituitary and ovary. These changes replicate those seen in humans with PCOS, suggesting that GnRH receptor‐activating autoantibodies might be involved in the pathogenesis of PCOS.
Journal Title: Experimental Physiology
Year Published: 2021
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