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Remote limb ischaemic conditioning produces cardioprotection in rats with testicular ischaemia–reperfusion injury

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What is the central question of this study? Can remote limb ischaemic conditioning produce cardioprotection in rats with testicular ischaemia–reperfusion injury? What is the main finding and its importance? Testicular… Click to show full abstract

What is the central question of this study? Can remote limb ischaemic conditioning produce cardioprotection in rats with testicular ischaemia–reperfusion injury? What is the main finding and its importance? Testicular ischaemia–reperfusion (TI/R)‐injured rats were predisposed to myocardial reperfusion‐induced atrioventricular block. Remote limb ischaemia preconditioning and postconditioning protected TI/R hearts against ischaemia‐provoked ventricular arrhythmia and ultimately reduced the incidence of sudden cardiac death, with a possible role of c‐Jun N‐terminal kinase inhibition and connexin 43 activation.

Keywords: remote limb; ischaemia; testicular ischaemia; reperfusion; ischaemia reperfusion

Journal Title: Experimental Physiology
Year Published: 2021

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