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The oestrous cycle and skeletal muscle atrophy: Investigations in rodent models of muscle loss

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What is the central question of this study? Is the oestrous cycle affected during disuse atrophies and, if so, how are oestrous cycle changes related to musculoskeletal outcomes? What is… Click to show full abstract

What is the central question of this study? Is the oestrous cycle affected during disuse atrophies and, if so, how are oestrous cycle changes related to musculoskeletal outcomes? What is the main finding and its importance? Rodent oestrous cycles were altered during disuse atrophy, which was correlated with musculoskeletal outcomes. However, the oestrous cycle did not appear to be changed by Lewis lung carcinoma, which resulted in no differences in muscle size in comparison to healthy control animals. These findings suggest a relationship between the oestrous cycle and muscle size during atrophic pathologies.

Keywords: cycle; atrophy; oestrous cycle; skeletal muscle; cycle skeletal

Journal Title: Experimental Physiology
Year Published: 2021

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