LAUSR

What is the central question of this study? What is the effect of an obesogenic diet on the expression of microRNAs (miRNAs) involved in cardiac hypertrophy in female mice? What is the main finding and its importance? Female mice fed an obesogenic diet exhibited cardiac hypertrophy associated with increased levels of miRNA‐143‐3p, decreased mRNA levels of Sox6 and increased mRNA levels of Myh7. Inhibition of miRNA‐143‐3p increased Sox6 mRNA levels and reduced Myh7 expression in cardiomyocytes, and prevented angiotensin II‐induced cardiomyocyte hypertrophy. The results indicate that the miRNA‐143‐3p–Sox6–Myh7 pathway may play a key role in obesity‐induced cardiac hypertrophy.