LAUSR

What is the central question of this study? Do Notch, Numb and Numb‐like expression change in human skeletal muscle after exercise‐induced muscle damage? What are the main finding and its importance? Notch gene expression trends toward an increase in response to an acute bout of exercise‐induced muscle damage, while Numb and Numb‐like expression does not change. These results suggest that human skeletal muscle response to exercise‐induced muscle damage is dynamic and may differ from Drosophila and rodent models. Furthermore, the timing of muscle biopsies, training status and muscle damage protocols should be considered.