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Oral ketone monoester supplementation does not accelerate recovery of muscle force or modulate circulating cytokine concentrations after muscle‐damaging eccentric exercise in healthy males and females

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What is the central question of this study? Does acute ketone monoester supplementation enhance the recovery of muscle force and modulate circulating cytokine concentrations after muscle‐damaging eccentric exercise? What is… Click to show full abstract

What is the central question of this study? Does acute ketone monoester supplementation enhance the recovery of muscle force and modulate circulating cytokine concentrations after muscle‐damaging eccentric exercise? What is the main finding and its importance? Ketone monoester supplementation increased plasma β‐hydroxybutyrate concentrations but did not attenuate the reduction in muscle force or the increase in plasma inflammatory cytokine concentrations that occurred after eccentric exercise. Notably we report novel data demonstrating a reduction in plasma TRAIL concentrations after eccentric exercise, highlighting TRAIL signalling as a possibly novel regulator of muscle recovery.

Keywords: monoester supplementation; muscle; eccentric exercise; muscle force; ketone monoester

Journal Title: Experimental Physiology
Year Published: 2022

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