LAUSR

What is the central question of this study? What are the effects of insulin and insulin‐induced hypoglycaemia on carotid body chemoreceptor activity in vivo and how do carotid body chemoreceptor stimulation‐mediated cardiorespiratory responses in beagle dogs compare during euglycaemia and insulin‐induced hypoglycaemia? What is the main finding and its importance? Intracarotid insulin administration leads to sustained increase in carotid body chemoreceptor activity and respiratory response with significant cardiovascular effects. Insulin‐induced hypoglycaemia exacerbated NaCN‐mediated carotid body chemoreceptor activity and respiratory response with enhanced cardiovascular reflex response. These findings suggest that insulin‐induced hypoglycaemia augments the carotid body chemoreceptors to initiate the adaptive counter‐regulatory responses to restore the normoglycaemic condition.