LAUSR

What is the central question of this study? Are biomarkers of endothelial function, oxidative stress and inflammation altered by non‐freezing cold injury (NFCI)? What is the main finding and its importance? Baseline plasma [interleukin‐10] and [syndecan‐1] were elevated in individuals with NFCI and cold‐exposed control participants. Increased [endothelin‐1] following thermal challenges might explain, in part, the increased pain/discomfort experienced with NFCI. Mild to moderate chronic NFCI does not appear to be associated with either oxidative stress or a pro‐inflammatory state. Baseline [interleukin‐10] and [syndecan‐1] and post‐heating [endothelin‐1] are the most promising candidates for diagnosis of NFCI.