LAUSR

The objective of this study was to use image-based CFD simulation techniques to analyze the impact that multiple closely spaced IAs of the supra-clinioid segment of the ICA have on each other's hemodynamic characteristics. The vascular geometry of fifteen (15) subjects with 2 IAs were gathered using a 3D clinical system. Two groups of computer models were created for each subject's vascular geometry: both IAs present (Model A) and after removal of one IA (Model B). Models were separated into two groups based on IA separation: tandem (one proximal and one distal) and tandem (aneurysms directly opposite on a vessel). Simulations using a pulsatile velocity waveform were solved by a commercial CFD solver. Proximal IAs altered flow into distal IAs (5 of 7), increasing flow energy and spatial-temporally averaged wall shear stress (STA-WSS: 3-50\% comparing Model A to B) while decreasing flow stability within distal IAs. Thus, proximal IAs may ``protect" a distal aneurysm from destructive remodeling due to flow stagnation. Among adjacent IAs, the presence of both IAs decreased each other's flow characteristics, lowering WSS (Model A to B) and increasing flow stability: all changes statistically significant (t-test p < 0.05). A negative relationship exists between the mean percent change in flow stability in relation to adjacent IA volume and ostium area. Closely spaced IAs impact hemodynamic alterations onto each other concerning flow energy, stressors and stability. Understanding these alterations may improve clinical management of closely-spaced IAs.