LAUSR.org creates dashboard-style pages of related content for over 1.5 million academic articles. Sign Up to like articles & get recommendations!

Microtopographies control the development of basal protrusions in epithelial sheets.

Photo by wulcan from unsplash

Cells are able to develop various types of membrane protrusions that modulate their adhesive, migratory, or functional properties. However, their ability to form basal protrusions, particularly in the context of… Click to show full abstract

Cells are able to develop various types of membrane protrusions that modulate their adhesive, migratory, or functional properties. However, their ability to form basal protrusions, particularly in the context of epithelial sheets, is not widely characterized. The authors built hexagonal lattices to probe systematically the microtopography-induced formation of epithelial cell protrusions. Lattices of hexagons of various sizes (from 1.5 to 19 μm) and 5-10 μm height were generated by two-photon photopolymerization in NOA61 or poly(ethylene glycol) diacrylate derivatives. The authors found that cells generated numerous, extensive, and deep basal protrusions for hexagons inferior to cell size (3-10 μm) while maintaining a continuous epithelial layer above structures. They characterized the kinetics of protrusion formation depending on scaffold geometry and size. The reported formation of extensive protrusions in 3D microtopography could be beneficial to develop new biomaterials with increased adhesive properties or to improve tissue engineering.

Keywords: control development; development basal; basal protrusions; basal; microtopographies control; epithelial sheets

Journal Title: Biointerphases
Year Published: 2018

Link to full text (if available)


Share on Social Media:                               Sign Up to like & get
recommendations!

Related content

More Information              News              Social Media              Video              Recommended



                Click one of the above tabs to view related content.