LAUSR

Abstract. Significance X-ray Cherenkov–luminescence tomography (XCLT) produces fast emission data from megavoltage (MV) x-ray scanning, in which the excitation location of molecules within tissue is reconstructed. However standard filtered backprojection (FBP) algorithms for XCLT sinogram reconstruction can suffer from insufficient data due to dose limitations, so there are limits in the reconstruction quality with some artifacts. We report a deep learning algorithm for XCLT with high image quality and improved quantitative accuracy. Aim To directly reconstruct the distribution of emission quantum yield for x-ray Cherenkov-luminescence tomography, we proposed a three-component deep learning algorithm that includes a Swin transformer, convolution neural network, and locality module model. Approach A data-to-image model x-ray Cherenkov-luminescence tomography is developed based on a Swin transformer, which is used to extract pixel-level prior information from the sinogram domain. Meanwhile, a convolutional neural network structure is deployed to transform the extracted pixel information from the sinogram domain to the image domain. Finally, a locality module is designed between the encoder and decoder connection structures for delivering features. Its performance was validated with simulation, physical phantom, and in vivo experiments. Results This approach can better deal with the limits to data than conventional FBP methods. The method was validated with numerical and physical phantom experiments, with results showing that it improved the reconstruction performance mean square error (>94.1  %  ), peak signal-to-noise ratio (>41.7  %  ), and Pearson correlation (>19  %  ) compared with the FBP algorithm. The Swin-CNN also achieved a 32.1% improvement in PSNR over the deep learning method AUTOMAP. Conclusions This study shows that the three-component deep learning algorithm provides an effective reconstruction method for x-ray Cherenkov-luminescence tomography.