LAUSR

Evidence from animal models of substantial noise-induced cochlear synaptopathy even in the absence of measurable audiometric changes has led to an active debate over whether such damage occurs in humans, and whether it contributes to suprathreshold-hearing deficits. Addressing these fundamental and translational questions requires multi-disciplinary approaches that integrate widely ranging forms of data and analyses, e.g., animal/human/model, evoked/single-unit/behavioral, and lab/clinical. Furthermore, connecting results across research groups around the world working on various species requires a systematic approach to resource sharing that will promote rigor and reproducibility. Here, we describe our efforts and plans to share resources from a large-scale collaborative project on noise-induced synaptopathy that links single-unit, evoked, and behavioral data from chinchillas with evoked, behavioral, and imaging data from humans studied in the laboratory and in the clinic. In addition to using modular im...