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SirT7 auto-ADP-ribosylation regulates glucose starvation response through mH2A1

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SirT7 is a dual enzyme that regulates energy deprivation response through a functional interaction with histone variant mH2A1. Sirtuins are key players of metabolic stress response. Originally described as deacetylases,… Click to show full abstract

SirT7 is a dual enzyme that regulates energy deprivation response through a functional interaction with histone variant mH2A1. Sirtuins are key players of metabolic stress response. Originally described as deacetylases, some sirtuins also exhibit poorly understood mono–adenosine 5′-diphosphate (ADP)–ribosyltransferase (mADPRT) activity. We report that the deacetylase SirT7 is a dual sirtuin, as it also features auto-mADPRT activity. SirT7 mADPRT occurs at a previously undefined active site, and its abrogation alters SirT7 chromatin distribution. We identify an epigenetic pathway by which ADP-ribosyl-SirT7 is recognized by the ADP-ribose reader mH2A1.1 under glucose starvation, inducing SirT7 relocalization to intergenic regions. SirT7 promotes mH2A1 enrichment in a subset of nearby genes, many of them involved in second messenger signaling, resulting in their specific up- or down-regulation. The expression profile of these genes under calorie restriction is consistently abrogated in SirT7-deficient mice, resulting in impaired activation of autophagy. Our work provides a novel perspective on sirtuin duality and suggests a role for SirT7/mH2A1.1 axis in glucose homeostasis and aging.

Keywords: sirt7 auto; glucose starvation; response; mh2a1

Journal Title: Science Advances
Year Published: 2020

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