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Structural Biology In the microbial world, the chemical diversity of secreted metabolites is vast, and their physiological roles are underexplored. Costa et al. studied the redox-active secondary metabolite pyocyanin, which… Click to show full abstract
Structural Biology In the microbial world, the chemical diversity of secreted metabolites is vast, and their physiological roles are underexplored. Costa et al. studied the redox-active secondary metabolite pyocyanin, which is produced by the opportunistic pathogen Pseudomonas aeruginosa. Pyocyanin mediates the generation of thick biofilms containing extracellular DNA that are important in pathogenesis. The authors characterized the demethylase PodA, which catalyzes the conversion of pyocyanin to hydroxyphenazine and deranges biofilm formation. PodA could represent a therapeutic lead for intractable bacterial infections. Science , this issue p. [170][1] [1]: /lookup/doi/10.1126/science.aag3180
Journal Title: Science
Year Published: 2017
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