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Metabolic memory in Mycobacterium.

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Tuberculosis Tuberculosis is a slow disease. Replication of the pathogen, Mycobacterium tuberculosis , can be arrested for decades within hypoxic tubercles. Eoh et al. show that hypoxia shifts the metabolism… Click to show full abstract

Tuberculosis Tuberculosis is a slow disease. Replication of the pathogen, Mycobacterium tuberculosis , can be arrested for decades within hypoxic tubercles. Eoh et al. show that hypoxia shifts the metabolism of M. tuberculosis into the pentose phosphate pathway (PPP) by depleting stores of trehalose

Keywords: metabolic memory; tuberculosis; mycobacterium; memory mycobacterium

Journal Title: Science
Year Published: 2017

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