LAUSR

Metabolism Roux-en-Y gastric bypass surgery (RYGB) is an effective treatment strategy for obesity. Whether RYGB-mediated weight loss is directly associated with the long-term metabolic benefits remains elusive. Ben-Zvi et al. studied the physiological adaptations of obese mice subjected to RYGB or calorie restriction and compared the results with data for post-RYGB patients. RYGB-operated mice displayed beiging of adipose tissue and short-term skeletal muscle adaptations not observed in calorie-restricted mice. Meanwhile, altered amino acid metabolism in the liver and intestinal immune and metabolic changes were conserved between RYGB-operated mice and humans. These integrated organ adaptations exhibited a time-dependent pattern of activation coordinated with the circadian clock network, providing evidence that metabolic changes associated with RYGB are not attributable to weight loss alone. Cell Metab. 10.1016/j.cmet.2018.06.004 (2018).