LAUSR

Inflammation Some tissues, such as the eye, limit immune cell infiltration. Sakurai et al. found that a modified form of cholesterol inhibited the guanine nucleotide exchange factor DOCK2 and thus suppressed neutrophil and T cell migration. In mice, cholesterol sulfate was produced by the gland that secretes the lipids that form the outer layer of the tear film covering the eye. Mice lacking the major sulfotransferase that produces cholesterol sulfate had increased infiltration of immune cells into the conjunctiva and cornea, which was reversed by topical application of cholesterol sulfate. Sci. Signal. 11 , eaao4874 (2018).