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GPCR Signaling Some of the single-nucleotide polymorphisms associated with type 2 diabetes occur in the gene that encodes the melatonin receptor MT2, a G protein–coupled receptor (GPCR). Karamitri et al.… Click to show full abstract
GPCR Signaling Some of the single-nucleotide polymorphisms associated with type 2 diabetes occur in the gene that encodes the melatonin receptor MT2, a G protein–coupled receptor (GPCR). Karamitri et al. measured the spontaneous and melatonin-stimulated signaling of 40 different MT2 variants. MT2 variants with defective melatonin-stimulated G protein signaling and reduced spontaneous β-arrestin recruitment were associated with the greatest risk for type 2 diabetes. These data may aid in developing specific type 2 diabetes treatments based on a patient's MT2 variant. Sci. Signal. 11 , eaan6622 (2018).
Journal Title: Science
Year Published: 2018
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