LAUSR

Antibodies Persistent immune activation during chronic infections is often associated with increased generation and deposition of immune complexes. The actions of antibody-based drugs can thus be severely impaired in individuals with chronic infections. Using lymphocytic choriomeningitis virus (LCMV) as a model of chronic infection, Wieland et al. examined how to enhance antibody functions in this setting. The ability of antibodies to deplete target cells was dependent on antigen expression levels. Furthermore, afucosylation of antibodies directed against CD4 and CD8α enhanced their ability to deplete CD4+ and CD8+ T cells in mice persistently infected with LCMV. Whether afucosylation can be universally used to enhance antibody functions during chronic infections remains to be seen. Sci. Immunol. 3 , eaao3125 (2018).